Vogue UA: Long and happy

Ukrainian professional brand Re[Sens] formulates its products based on the principles of neurocosmetics — using ingredients that reduce free cortisol and stimulate endorphins.

Modern cosmetology is now focusing on a new generation of skincare — products that not only act directly on the skin but also help regulate stress levels and emotional well-being, thereby influencing skin function and condition.

Neurocosmetics lower free cortisol levels and stimulate endorphin production.

Serotonin, endorphins, oxytocin — all of these are neurotransmitters, or simply “happy hormones,” produced by the brain. They enhance mood and well-being — and also affect the skin:

  • Serotonin helps fight inflammation
  • Endorphins soothe itchiness and irritation
  • Oxytocin speeds up healing and regeneration

In contrast, excess cortisol — the stress hormone — leads to puffiness, under-eye bags, double chins, and sagging facial contours. Nearly all dermatological issues — atopic dermatitis, psoriasis, rosacea, acne — tend to flare up “under stress.”

The skin is an autonomous mini nervous system capable of synthesizing cortisol and serotonin.

While neurotransmitters are produced in the brain and cortisol in the adrenal glands, the skin can also synthesize them on its own. It contains enzymes necessary for this. Essentially, it’s a self-contained mini nervous system that autonomously responds to stress and stimuli — even triggering local production of cortisol or serotonin. These processes can be influenced externally — which is exactly what neurocosmetics do.

Re[Sens] uses a neurocosmetic approach: the products care for the skin while also influencing its “emotional state.” Neurosensory peptides and plant stem cells help reduce stress by lowering free cortisol levels and stimulating endorphin synthesis.

A-Redensity line for sensitive skin

A-Redensity Hydra Cream and A-Redensity Matt Cream contain neurosensory peptides that protect against environmental stressors. Fructooligosaccharides, bioflavonoids, and glycoproteins in the formulas activate the D-SKIN mechanism — the skin's ability to synthesize its own vitamin D. This helps saturate the epidermis with moisture and oxygen, giving the complexion a natural glow.

3Action Exosome Boost line

3Action Exosome Boost Serum, 3Action Exosome Boost Cream, and 3Action Exosome Boost Eye Cream contain Sichuan pepper extract. It works similarly to Botox — relaxing facial muscles.

The skin recognizes the scent of the extract through bitterness-sensitive receptors, which send a signal via nerve endings to relax. As a result, the face looks calm, and you feel refreshed — as if after rest.

Neuroaging is the aging of skin nerve cells, leading to loss of tone and wrinkle formation.

In the near future, neurocosmetics may be used to treat age-related conditions. Scientists are already researching neurodegenerative diseases like Parkinson’s and Alzheimer’s — conditions linked to aging and nervous system degradation.

Now, attention is turning to how skin neurons also age. The new term “neuroaging” describes the changes that occur after age 50 — particularly in women — as neurons become less sensitive and cells respond less to active ingredients in skincare.

As a result, fibroblasts — the cells responsible for collagen production and skin firmness — “slow down,” and the skin begins to age faster, losing tone and forming wrinkles.

To prevent this, skincare includes ingredients that “wake up” neurons, restoring their sensitivity and responsiveness — such as Sichuan pepper extract, neuropeptides, and neurotransmitter stimulators (like cocoa, caffeine, and ginseng extracts).

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