Immunocosmetology is a contemporary skincare direction that works with the skin’s internal defence resources, rather than merely addressing irritation or inflammation symptoms. Unlike traditional care, immunocosmetics don’t mask symptoms — they modulate local (epidermal) immunity, helping the skin restore balance, reduce reactivity, and maintain stable barrier function.

Re[Sens]

Skin’s immune system includes...

... immune cells (Langerhans cells, keratinocytes), the microbiome, and signalling molecules — forming the first line of defense against external threats. Immunocosmetics gently interact with these structures via active ingredients that:strengthen the barrier, reduce hyperreactivity, support the microbiome, regulate inflammatory responses

In immunocosmetic care, lactobacilli are seen not only as prebiotics or microbiome modifiers, but as true modulators of innate skin immunity. Their activity occurs through interaction with epidermal cells (notably keratinocytes), induction of antimicrobial peptides, and modulation of pro-inflammatory signalling pathways.

This enables targeting critical immune mechanisms in sensitive skin:

  • reduced colonization by pathogens (especially Staphylococcus aureus)
  • stabilized microbiome
  • decreased neuro‑immune reactivity
  • restored barrier integrity

The A‑REDENSITY line

features a postbioticLactobacillus casei at a clinically effective dose (1×10¹² CFU/g), offering immunomodulatory effects and promoting microbiome balance restoration.
A‑REDENSITY

Mechanisms include:

Immune activation via antimicrobial peptides: L. casei stimulates β-defensin and LL-37 production, suppressing S. aureus, a key trigger of inflammatory dermatoses and skin sensitization.
Support of CoNS flora (coagulase‑negative staphylococci): Commensal flora naturally competes with pathogens, regulates sebum, and reduces TLR signalling in keratinocytes. Its level declines tenfold with age, directly linked to skin hypersensitivity.
Neuro-immune stabilization: Fewer pathogens → less TLR activation → lower sensory neuron load → reduced hyperreactivity.
Immune activation via antimicrobial peptides: L. casei stimulates β-defensin and LL-37 production, suppressing S. aureus, a key trigger of inflammatory dermatoses and skin sensitization.
Support of CoNS flora (coagulase‑negative staphylococci): Commensal flora naturally competes with pathogens, regulates sebum, and reduces TLR signalling in keratinocytes. Its level declines tenfold with age, directly linked to skin hypersensitivity.
Neuro-immune stabilization: Fewer pathogens → less TLR activation → lower sensory neuron load → reduced hyperreactivity.

A‑REDENSITY follows the principle: “greater microbial diversity = less sensitivity, greater healthy glow,” delivering optimal barrier function and skin hydrobalance.

Amino acids are not just protein building blocks

They also act as signalling molecules regulating epidermal barrier, metabolism, and immune activity. In an immunocosmetic framework, they serve as physiological modulators that restore stratum corneum integrity, support hydration, and reduce skin inflammatory reactivity.
CleanUP Powder

The innovative CleanUP Powder formula

— unique globally — contains 14 pure amino acids chosen to support both structure and function of the stratum corneum. The complex mimics the physiological amino acid profile of NMF (Natural Moisturizing Factor) and the modulatory action of placental peptides, feeding cells and building tolerance even in sensitized skin.

Key functions:

  • regeneration: proline, glycine, serine, glutamic acid assist in synthesis of epidermal proteins (filaggrin, involucrin);
  • hydration: amino acids act as osmolytes, binding moisture and maintaining electrolyte stability;
  • immunomodulation: arginine, taurine, histidine exhibit antioxidant and anti-inflammatory properties, reducing pro-inflammatory cytokine production;
  • textural correction: leucine, isoleucine, phenylalanine remodel microrelief, enhancing smoothness and density

The amino acid system in CleanUP Powder not only compensates for NMF losses but also actively engages in recovery processes — reducing sensitivity, flaking, and microinflammation..